Various traditions interpret moha in slightly different ways. In the Buddhist tradition of Theravada, moha is described as ignorance of the nature of reality, or avidya. In the Mahayana tradition, it is considered to be the state of mind that this ignorance causes: a state of confusion and not knowing what to do.
Suffering cannot cease until moha is removed. In Buddhism, avidya, and the two other “unwholesome roots” of craving and attachment, all together prolong the cycle of rebirth and suffering.